Expression and function of NFAT5 in medullary thick ascending limb (mTAL) cells
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چکیده
منابع مشابه
Expression and function of NFAT5 in medullary thick ascending limb (mTAL) cells.
The contribution of nuclear factor of activated T cells 5 (NFAT5) to the regulation of tumor necrosis factor-alpha (TNF) production in medullary thick ascending limb (mTAL) cells is unclear. RT-PCR analysis was performed on primary cultures of mouse mTAL cells and freshly isolated mTAL tubules to determine which NFAT isoforms are present in this nephron segment. Primer pairs were designed, base...
متن کاملBasolateral P2X receptors mediate inhibition of NaCl transport in mouse medullary thick ascending limb (mTAL).
Extracellular nucleotides regulate epithelial transport via luminal and basolateral P2 receptors. Renal epithelia express multiple P2 receptors, which mediate significant inhibition of solute absorption. Recently, we identified several P2 receptors in the medullary thick ascending limb (mTAL) including luminal and basolateral P2Y(2) receptors (Jensen ME, Odgaard E, Christensen MH, Praetorius HA...
متن کاملAmmonium carriers in medullary thick ascending limb.
Absorption of NH(4)(+) by the medullary thick ascending limb (MTAL) is a key event in the renal handling of NH(4)(+), leading to accumulation of NH(4)(+)/NH(3) in the renal medulla, which favors NH(4)(+) secretion in medullary collecting ducts and excretion in urine. The Na(+)-K(+)(NH(4)(+))-2Cl(-) cotransporter (BSC1/NKCC2) ensures approximately 50-65% of MTAL active luminal NH(4)(+) uptake un...
متن کاملDifferential regulation of NFAT 5 by NKCC 2 isoforms in medullary thick ascending limb 3 ( mTAL ) cells 4 5
26 27 The effects of Na-K-2Cl cotransporter type 2 (NKCC2) isoforms on the regulation of nuclear 28 factor of activated T cells isoform 5 (NFAT5) was determined in mouse medullary thick ascending 29 limb (mTAL) cells exposed to high NaCl concentration. Primary cultures of mTAL cells and freshly 30 isolated mTAL tubules, both derived from outer medulla (outer stripe>inner stripe), express NKCC2 ...
متن کاملHypertonicity increases CLC-5 expression in mouse medullary thick ascending limb cells.
Genetic studies indicated that mutations of the chloride channel CLC-5 in the kidney are responsible for a group of clinical disorders, collectively called Dent's disease. In the kidney, CLC-5 was found to be expressed in the proximal tubule, medullary thick ascending limb (mTAL) of loop of Henle, and intercalated cells of the collecting tubule. In proximal tubular cells, CLC-5 was found to pla...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2007
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.21.6.a1333-d