Exposure to Sidestream Tobacco Smoke Induces Airway Hyperresponsiveness and Inflammation in Early Postnatal Mice
نویسندگان
چکیده
منابع مشابه
Prenatal and Early, but Not Late, Postnatal Exposure of Mice to Sidestream Tobacco Smoke Increases Airway Hyperresponsiveness Later in Life
BACKGROUND Cigarette smoke exposure in utero and during early postnatal development increases the incidence of asthma and airway hyperresponsiveness (AHR) later in life, suggesting that a possible critical period of developmental sensitivity exists in the prenatal and early postnatal periods. OBJECTIVE We investigated mechanisms of susceptibility during critical developmental periods to sides...
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BACKGROUND AND OBJECTIVE Asthma is one of the most common airway inflammatory diseases. In most cases, asthma development is related to ubiquitous harmful environmental exposure factors in early-life. Previous studies have indicated that smoking can promote asthma development and increase the difficulty of asthma control. The aim of this study was to determine the effects of early-life CS expos...
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BACKGROUND Sidestream smoke is closely associated with airway inflammation and hyperreactivity. The present study was designed to investigate if the Raf-1 inhibitor GW5074 and the anti-inflammatory drug dexamethasone suppress airway hyperreactivity in a mouse model of sidestream smoke exposure. METHODS Mice were repeatedly exposed to smoke from four cigarettes each day for four weeks. After t...
متن کاملEarly postnatal exposure of mice to side-steam tobacco smoke increases neuropeptide Y in lung.
Our recent study showed that prenatal and early postnatal exposure of mice to side-steam tobacco smoke (SS), a surrogate to environmental tobacco smoke (ETS), leads to increased airway responsiveness and sensory innervation later in life. However, the underlying mechanism initiated in early life that affects airway responses later in life remains undefined. The concomitant increase in nerve gro...
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Nasal mucociliary clearance (NMC) is a biomarker of nasal mucosal function. Tobacco smokers have been shown to have abnormal NMC, but the acute effect of environmental tobacco smoke (ETS) on nonsmokers is unknown. This study evaluated acute tobacco smoke-induced alterations in NMC in 12 healthy adults. Subjects were studied on 2 days, separated by at least 1 week. Subjects underwent a 60-min co...
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ژورنال
عنوان ژورنال: Journal of Allergy & Therapy
سال: 2013
ISSN: 2155-6121
DOI: 10.4172/2155-6121.1000153