Exploiting sequence and stability information for directing nanobody stability engineering
نویسندگان
چکیده
منابع مشابه
Exploiting sequence and stability information for directing nanobody stability engineering
BACKGROUND Variable domains of camelid heavy-chain antibodies, commonly named nanobodies, have high biotechnological potential. In view of their broad range of applications in research, diagnostics and therapy, engineering their stability is of particular interest. One important aspect is the improvement of thermostability, because it can have immediate effects on conformational stability, prot...
متن کاملExploiting Passive Stability for Hierarchical Control
The dynamics of a Spring Loaded Inverted Pendulum (SLIP) \template” [1] approximate well the center of mass (COM) of running animals, humans, and of the robot RHex [2]. Running control can therefore be ierarchically structured as a high level SLIP control and the anchoring of SLIP in the complex morphology of the physical system. Analysis of the sagittal plane lossless SLIP model has shown that...
متن کاملassessing political stability and instability in central asia and caucasus; case study, azerbaijan and kyrgyzstan
منطقه ی آسیای مرکزی وقفقاز به عنوان منطقه ای تاریخی و به دلیل دارا بودن ذخایر عظیم هیدرو کربنی از اهمیت ویژه ای برخوردار است. کشورهای این منطقه از عوامل عمده ی بی ثباتی نظیر عوامل جغرافیایی، اقتصادی، امنیتی، اجتماعی و سیاسی رنج می برند. پس از فروپاشی اتحاد جماهیر شوروی کشورهای منطقه از نعمت استقلال ناخواسته ای برخوردار شدند که مشکلات فوق را برای آن ها چندین برابر می کرد. در این روند برخی از این...
15 صفحه اولState Stability: Exploiting System Dynamics
In its Preface, The 9/11 Commission Report states: “We learned that the institutions charted with protecting ...national security did not understand how grave this threat can be, and did not adjust their policies, plans, and practices to deter or defeat it” (2004: xvi). Given current realities and uncertainties “better preparedness” can be achieved by identifying, controlling and managing the e...
متن کاملon the global asymptotic stability for a rational recursive sequence
the main objective of this paper is to study the boundedness character, the periodicity character, the convergenceand the global stability of the positive solutions of the nonlinear rational difference equation/ , n 0,1,2,....0 01 kii n ikin i n i x x b xwhere the coefficients i i b , , together with the initial conditions ,.... , , 1 0 x x x k are arbitrary...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - General Subjects
سال: 2017
ISSN: 0304-4165
DOI: 10.1016/j.bbagen.2017.06.014