Experimental Verification of Conformational Variation of Human Fatty Acid Synthase as Predicted by Normal Mode Analysis
نویسندگان
چکیده
منابع مشابه
Experimental verification of conformational variation of human fatty acid synthase as predicted by normal mode analysis.
Fatty acid synthase (FAS) is a 550 kDa homodimeric enzyme with multiple functional and structural domains. Normal mode analysis of a previously determined 19 A structure of FAS suggested that this enzyme might assume different conformational states with several distinct hinge movements. We have used a simultaneous multiple-model refinement method to search for the presence of the structural con...
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ژورنال
عنوان ژورنال: Structure
سال: 2004
ISSN: 0969-2126
DOI: 10.1016/j.str.2004.01.015