منابع مشابه
Experimental Therapeutics Programme
Additional targeted projects, focused on Mastl and Haspin inhibitors, are undertaken in collaboration with Marcos Malumbres ( CNIO Cell Division and Cancer Group ). The Mastl project started with a cell-based screening of several ETP-libraries, where a few ‘ high-micromolar ’ hits emerged as potential Mastl inhibitors. However, a direct target engagement experiment to unequivocally identify Mas...
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The increasing development of novel gene and targeted therapies for treating tumors has necessitated the development of imaging approaches to determine their efficacy in preclinical animal models. This overview will provide selected examples of using imaging for quantitating tumor cell kill (anatomical and diffusion MRI), early treatment-induced changes in tumor cellularity/metabolism (diffusio...
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Three decades after its introduction, levodopa remains the gold standard for the treatment of Parkinson’s disease (PD). Levodopa is the most potent symptomatic antiparkinsonian agent, and it is associated with an increase in quality of life and longevity for patients with PD. Dopamine agonists are increasingly being used, not only as an adjunct to levodopa, but as early therapy aimed at reducin...
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Currently, numerous effective pharmacologic and behavioral therapies are available for the treatment of opioid addiction, and these two types of therapies often are combined to optimize patient management. Newer therapeutic options may take various forms. For example, methadone maintenance is an established treatment modality, whereas the use of buprenorphine and naloxone in an office-based set...
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Spontaneous lymphoma is a frequently occurring disease in the canine species. These neoplasms are remarkably similar to their counterpart in humans with respect to histol ogy, anatomic sites of involvement, and biologic behavior. In the present study, dogs with biopsy proven lymphoma were treated with total-body irradiation and objective remissions of disease were observed. A small group of pat...
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ژورنال
عنوان ژورنال: Journal of the American Medical Association
سال: 1912
ISSN: 0002-9955
DOI: 10.1001/jama.1912.04260010244004