Experimental Ocular Syphilis and Neurosyphilis

Experimental Ocular Syphilis and Neurosyphilis.

The challenge in clinical syphilis to-day is the detection of the disease in the sero-negative patient. The magnitude of this problem is evident when one considers that over 100 cases of ocular syphilis and neurosyphilis have been encountered in this institution within the past year (Smith, 1964; Smith and Moore, 1964; Smith and Taylor, 1965). Ofparamount importance is the fact that the majorit...

Experimental ocular and neurosyphilis in the primate.

The rabbit has been commonly used for experimental syphilis since Bertarelli (1906) first inoculated this species with Treponema pallidum. Three years earlier, Metchnikoff and Roux (1906) had succeeded in making the monkey the first animal successfully inoculated with the disease. However, but for isolated and notable exceptions (Neisser, 1906, 1908; Turner and Hollander, 1957), few subsequent ...

Neurosyphilis (Syphilis of the Nervous System)

Neurosyphilis after treatment of latent syphilis with benzathine penicillin.

Two patients developed neurosyphilis after treatment of latent syphilis with intramuscular benzathine penicillin. The cases confirm recent investigations that show that neither benzathine penicillin nor procaine penicillin in the standard doses results in treponemicidal concentrations of penicillin in cerebrospinal fluid. Neurosyphilis can be treated effectively by intravenous benzylpenicillin ...

Ocular Syphilis in a Kidney Transplant Recipient

We present a case of ocular syphilis after a renal transplantation involving progressive vision loss without clinically identifiable ocular disease. Electroretinography showed signs of ischemia, especially in the internal retina. A serological test was positive for syphilis. Lumbar puncture revealed lymphocytic meningitis and a positive serologic test for syphilis in the cerebrospinal fluid. Th...