Experimental charge density ofDL-serine andL-serine
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چکیده
منابع مشابه
Purification of serine racemase: biosynthesis of the neuromodulator D-serine.
High levels of D-serine occur in mammalian brain, where it appears to be an endogenous ligand of the glycine site of N-methyl-D-aspartate receptors. In glial cultures of rat cerebral cortex, D-serine is enriched in type II astrocytes and is released upon stimulation with agonists of non-N-methyl-D-aspartate glutamate receptors. The high levels of D-serine in discrete areas of rat brain imply th...
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A remarkable feature of the serine resolvases is their regulation: the wild-type enzymes will catalyse intra- but not inter-molecular recombination, can sense the relative orientation of their sites and can exchange strands directionally, despite the fact that there is no net release of chemical bond energy. The key to this regulation is that they are only active within a large intertwined comp...
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Several products of CTL and NK cells, including a pore-forming protein (PFP;t perforin or cytolysin) (1-4) and several serine esterases (SE) (5-12), have been cloned and sequenced . These proteins are localized to cytoplasmic granules and represent the known structural components ofthe pore-formation and granule exocytosis models for cell-mediated killing (13-17). Granule mediators are expresse...
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In an investigation of transamination reactions between pyridoxal and amino acids at 100” (2) serine was found to behave anomalously, apparently being deaminated to pyruvic acid with little change in pyridoxal concentration. Although serine is known to be deaminated by hot concentrated alkalies (3) and acids (4), such a non-enzymatic reaction in the pH range near neutrality has not been reporte...
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1 (1-1) and inhibitor-2 (1-2), and preferentially dephosphorylate the /3-subunit of phosphorylase kinase, whereas type-2 phosphatases are insensitive to the heat-stable inhibitors and preferentially dephosphorylate the x-subunit of phosphorylase kinase [1,2]. Type-2 phosphatases can be further subdivided into spontaneously active (PP2A), Ca2l-dependent (PP2B) and Mg2+dependent (PP2C) classes. T...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations of Crystallography
سال: 1996
ISSN: 0108-7673
DOI: 10.1107/s0108767396085662