EXPERIMENTAL ANTICANCER STUDIES. PART 12

Part 12. Systematic desensitization.

Ontological Modeling : Part 12

This is the twelfth in a series of articles on ontology-based approaches to modeling. The main focus is on popular ontology languages proposed for the Semantic Web, such as the Resource Description Framework (RDF), RDF Schema (RDFS), and the Web Ontology Language (OWL). OWL is based on description logic. A later series of articles will explore other logic-based languages such as datalog. The fi...

Molecular docking studies on xanthohumol derivatives as novel ‎anticancer agents ‎

A set of Xanthohumol derivatives were selected and molecular docking studies of these ‎compounds on thioredoxin reductase were conducted. Based on new structural patterns using in ‎silico-screening study, new potent lead compounds were designed. The results due to validated ‎docking protocols lead to find that Thr58, Gly57, Gly21, Asp334, Glu163, Ala130, IIe332, ‎Val44 and Gly132 are the main a...

Dual-Target Anticancer Drug Candidates: Rational Design and Simulation Studies

This study aims to design some dual-target anticancer candidates, capable to act as an alkylating agent as well as a thymidylate synthase (TS) inhibitor. The designed scaffold is a combination of nucleobase, amino acid and aziridine structures. The candidates are docked into TS and three DNA double strand structures and evaluated based on their binding interaction energies and ligand efficienci...

Pharmacological studies of anticancer, anti inflammatory activities of Murraya koenigii (Linn) Spreng in experimental animals

The aim of the present study is to evaluate the effect of column (SU I, SU II, SU III) extracts of the plant Murraya koenigi against in vitro (short term incubation method, SU I, SU II, SU III) and in vivo (Dalton’s Ascitic Lymphoma, SU II) has been evaluated in male swiss albino mice. DAL cells were injected intraperitoneally (10 cells) to the mice. Two days after cells injection the animals w...