Experimental Animal Models and Human Disease
نویسندگان
چکیده
منابع مشابه
Cholestasis: human disease and experimental animal models.
Cholestasis may result from a failure in bile secretion in hepatocytes or ductular cells, or from a blockade to the free bile flow. Human cholestasis may be induced by many drugs, being antibiotics the more common. Other types of cholestasis seen in humans are a group of familial cholestatic disorders, obstructive cholestasis, primary biliary cirrhosis, extrahepatic biliary atresia, primary scl...
متن کاملAnimal and cellular models of human disease.
In this eighteenth (2016) Annual Review Issue of The Journal of Pathology, we present a collection of 19 invited review articles that cover different aspects of cellular and animal models of disease. These include genetically-engineered models, chemically-induced models, naturally-occurring models, and combinations thereof, with the focus on recent methodological and conceptual developments acr...
متن کاملAnimal models for human polycystic kidney disease.
Polycystic kidney disease (PKD) is a hereditary disorder with abnormal cellular proliferation, fluid accumulation in numerous cysts, remodeling of extracellular matrix, inflammation, and fibrosis in the kidney and liver. The two major types of PKD show autosomal dominant (ADPKD) or autosomal recessive inheritance (ARPKD). ADPKD is one of the most common genetic diseases, with an incidence of 1:...
متن کاملEngineering large animal models of human disease
The recent development of gene editing tools and methodology for use in livestock enables the production of new animal disease models. These tools facilitate site-specific mutation of the genome, allowing animals carrying known human disease mutations to be produced. In this review, we describe the various gene editing tools and how they can be used for a range of large animal models of disease...
متن کاملInvited Review ANIMAL MODELS OF HUMAN LUNG DISEASE Animal models of chronic obstructive pulmonary disease
Wright JL, Cosio M, Churg A. Animal models of chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol 295: L1–L15, 2008. First published May 2, 2008; doi:10.1152/ajplung.90200.2008.—The mechanisms involved in the genesis of chronic obstructive pulmonary disease (COPD) are poorly defined. This area is complicated and difficult to model because COPD consists of four separate ana...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 1979
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(79)80238-3