Experimental and Established Oximes as Pretreatment before Acute Exposure to Azinphos-Methyl

Electrooxidation as a Pretreatment Process Before Cyanidation

Statin pretreatment in experimental acute pancreatitis.

CONTEXT Some authors have found beneficial effect of statins in certain inflammatory conditions, but the effect of statins on acute pancreatitis is not yet defined. OBJECTIVE The aim of this study was to evaluate the effect of simvastatin on an experimental model of mild and severe acute pancreatitis. ANIMALS One hundred and one Wistar rats with cerulein or taurocholate-induced acute pancre...

Biochemical and Hematological Effect of Cordyla pinnata Following Acute and Sub-Acute Exposure to Rattus norvegicus

Background: Cordyla pinnata (C. pinnata) is commonly used in traditional medicine for the treatment of various ailments. The aim of this study was to assess the toxic and safety potentials of the methanol extract of C. pinnata in rats.  Methods: The methanol extract of C. pinnata was administered to the rats orally once daily at a dose of 0, 150, 300 or 600 mg/kg, body weight for 21 days. The ...

Injury to skeletal muscle of mice following acute and sub-acute pregabalin exposure

Objective(s): Pregabalin (PGB) is a new antiepileptic drug that has received FDA approval for patient who suffers from central neuropathic pain, partial seizures, generalized anxiety disorder, fibromyalgia and sleep disorders. This study was undertaken to evaluate the possible adverse effects of PGB on the muscular system of mice. Materials and Methods: To evaluate the effect of PGB on skeletal...

Evaluation of Morphological and Mitochondrial Alterations of Mouse Fetus after Exposure to Methyl tert-butyl Ether

Although the biokinetics, metabolism, and chemical toxicity of methyl tert-butyl ether are well known, little attention was paid to the potential toxic effects of MTBE on reproduction and development in mammals. To evaluate the effects of MTBE on pregnant animals, two groups (control and test) of NMRI mice were chosen. In test group 500 and 1000 mg/Kg of it were administered intraperitonealy at...