Expanded Anticancer Therapeutic Window of Hexon-modified Oncolytic Adenovirus
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چکیده
منابع مشابه
Fiber-modified hexon-chimeric oncolytic adenovirus targeting cancer associated fibroblasts inhibits tumor growth in gastric carcinoma
Objective To evaluate the effects of fiber-modified hexon-chimeric recombinant oncolytic adenovirus targeting cancer associated fibroblasts (CAFs) on the gastric CAFs and the transplantation tumor mice model of gastric carcinoma (GC). Results Compared with BJ cells and GPFs, the reproduction and infectivity of P9, P9-4C or GP adenoviruses were markedly higher in gastric CAFs. In addition, P9,...
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متن کاملIdentification of Adenovirus Serotype 5 Hexon Regions
24 Most of an intravenous dose of species C adenovirus serotype 5 (Ad5) is 25 destroyed by liver Kupffer cells. In contrast, another species C virus, Ad6, evades these 26 cells to mediate more efficient liver gene delivery. Given that this difference in Kupffer 27 cell interaction is mediated by the hypervariable (HVR) loops of the virus hexon protein, 28 we genetically modified each of the sev...
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This is an accepted version of a paper published in Journal of Virology. This paper has been peer-reviewed but does not include the final publisher proof-corrections or journal pagination. Access to the published version may require subscription. ABSTRACT 20 Adenovirus serotype 5 (Ad5) is widely used as an oncolytic agent for cancer therapy. 21 However, its infectivity is highly dependent on th...
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2009
ISSN: 1525-0016
DOI: 10.1038/mt.2009.217