Exocyst complex subunit sec8 binds to postsynaptic density protein-95 (PSD-95): a novel interaction regulated by cypin (cytosolic PSD-95 interactor)

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Exocyst complex subunit sec8 binds to postsynaptic density protein-95 (PSD-95): a novel interaction regulated by cypin (cytosolic PSD-95 interactor).

The PDZ domains of postsynaptic density (PSD) protein-95 play a role in the localization of PSD-95 and binding partners to neuronal synapses. The identification of binding partners to these PDZ domains can help us in understanding how signalling complexes are assembled. We observed that one of the subunits in the sec6/8 or exocyst complex, sec8, contains a C-terminal consensus sequence for PDZ ...

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Postsynaptic density 95 (PSD-95/SAP-90) is a membrane associated guanylate kinase (GK) PDZ protein that scaffolds glutamate receptors and associated signaling networks at excitatory synapses. Affinity chromatography identifies cypin as a major PSD-95-binding protein in brain extracts. Cypin is homologous to a family of hydrolytic bacterial enzymes and shares some similarity with collapsin respo...

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Cellular/Molecular PSD-95 Uncouples Dopamine–Glutamate Interaction in the D1/PSD-95/NMDA Receptor Complex

Jingping Zhang,1 Tai-Xiang Xu,1 Penelope J. Hallett,2 Masahiko Watanabe,3 Seth G. N. Grant,4 Ole Isacson,2 and Wei-Dong Yao1 1New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, 2McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, 3Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060-8638, Japan, and 4Wellcome ...

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ژورنال

عنوان ژورنال: Biochemical Journal

سال: 2003

ISSN: 0264-6021,1470-8728

DOI: 10.1042/bj20021838