Exercise, Stand Up, Flip a Coin, or Just Say No

Exercise, stand up, flip a coin, or just say no: provocative testing in the child with borderline QTc.

The 2011 challenge in considering a diagnosis of long-QT syndrome (LQTS) is best viewed as having 4 distinct clinical scenarios. The first and most straightforward is the family member with a genotyped kindred in whom, within a month, a relatively firm diagnosis can be obtained by familyspecific testing, along with an ECG. The second, the genotype-negative index patient with otherwise unexplain...

Don't just stand there. Say something!

Ray Kurzweil and Uploading: Just Say No!

There is a debate about the possibility of mind-uploading – a process that purportedly transfers human minds and therefore human identities into computers. This paper bypasses the debate about the metaphysics of mind-uploading to address the rationality of submitting yourself to it. I argue that an ineliminable risk that mind-uploading will fail makes it prudentially irrational for humans to un...

Just say NO: nitric oxide regulation of Hsp90.

The 90 kDa heat-shock protein (Hsp90) was first identified as being expressed in response to elevated temperature. Since this initial observation, Hsp90 has been shown to be a molecular chaperone heavily involved in the regulation of signal transduction through its crucial role in folding and stabilizing hundreds of proteins that constitute nodal points in numerous signalling pathways (www.pica...

Just Say No: Benefits of Early Cache Miss Determinatio

As the performance gap between the processor cores and the memory subsystem increases, designers are forced to develop new latency hiding techniques. Arguably, the most common technique is to utilize multi-level caches. Each new generation of processors is equipped with higher levels of memory hierarchy with increasing sizes at each level. In this paper, we propose 5 different techniques that w...