Exercise-induced suppression of acylated ghrelin in humans

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Exercise-induced suppression of acylated ghrelin in humans.

Ghrelin is an orexigenic hormone secreted from endocrine cells in the stomach and other tissues. Acylation of ghrelin is essential for appetite regulation. Vigorous exercise induces appetite suppression, but this does not appear to be related to suppressed concentrations of total ghrelin. This study examined the effect of exercise and feeding on plasma acylated ghrelin and appetite. Nine male s...

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Effects of moderate intensity exercise training on appetite, acylated ghrelin and leptin levels in obese and untrained women

Introduction: Appetite affected energy homeostasis, it play an important role in control and regulation of energy balance. The purpose of this study was to investigate the effect of moderate intensity exercise training on appetite, acylated ghrelin and leptin levels in obese and untrained women. Methods: The research method was semi-experimental. The sample group was made of 25 subjects random...

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Insulin is required for prandial ghrelin suppression in humans.

Accumulating evidence indicates that ghrelin plays a role in regulating food intake and energy homeostasis. In normal subjects, circulating ghrelin concentrations decrease after meal ingestion and increase progressively before meals. At present, it is not clear whether nutrients suppress the plasma ghrelin concentration directly or indirectly by stimulating insulin secretion. To test the hypoth...

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Meal anticipation potentiates postprandial ghrelin suppression in humans.

Circulating concentrations of the orexigenic hormone ghrelin show a postprandial decrease in dependence on meal size and composition. Cognitive determinants of postprandial ghrelin suppression in humans are largely unexplored. We assessed the effects of cued meal anticipation on pre- and postprandial concentrations of total plasma ghrelin, pancreatic polypeptide and leptin as well as on markers...

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Antifibrotic Activity of Acylated and Unacylated Ghrelin

Fibrosis can affect almost all tissues and organs, it often represents the terminal stage of chronic diseases, and it is regarded as a major health issue for which efficient therapies are needed. Tissue injury, by inducing necrosis/apoptosis, triggers inflammatory response that, in turn, promotes fibroblast activation and pathological deposition of extracellular matrix. Acylated and unacylated ...

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ژورنال

عنوان ژورنال: Journal of Applied Physiology

سال: 2007

ISSN: 8750-7587,1522-1601

DOI: 10.1152/japplphysiol.00759.2006