Exendin-4 decreases amphetamine-induced locomotor activity
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چکیده
منابع مشابه
Exendin-4 potently decreases ghrelin levels in fasting rats.
Ghrelin is a potent orexigenic and adipogenic hormone that strongly influences fat deposition and the generation of hunger in obesity. Indeed, hyperghrelinemia appears to promote an increase in food intake as seen in Prader-Willi Syndrome (PWS). Exendin (Ex)-4 is an agonist of the glucagon-like peptide (GLP)-1 receptor (GLP-1r) that has anorexigenic and fat-reducing properties. Here, we report ...
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The synthesis of fully deuterated amphetamine (phenyl-2-aminopropane-d11) in which 11 deuterium atoms are bonded to carbons and two other highly deuterated analogues is described. Their toxicities and in vivo spontaneous locomotor activities in mice were examined and compared with that of the parent protioamphetamine. A significant reduction in toxicities and a decrease in spontaneous locomotor...
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Evidence suggests that CART (cocaine-amphetamine regulated transcript) peptides are mediators or modulators of the actions of psychostimulant drugs. In this study, the effects of intra-accumbal injections of rat long form (rl) CART 55-102 were examined. Injection of the peptide alone had no effect, but pretreatment with the peptide blunted or reduced the locomotor-inducing effects of cocaine af...
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OBJECTIVES Effects of acute exposure to organophosphorous pesticides (OPs), chlorphenvinphos (CVP) or chlorphyriphos (CPF) on amphetamine (AMPH)- or scopolamine (SCOP)-induced open-field locomotion were compared in rats. MATERIALS AND METHODS CVP and CPF were administered intraperitoneally, both at doses resulting in about 50% inhibition of erythrocyte acetylcholinesterase (rbcAChE). The pest...
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The effects of amphetamine and cocaine on locomotor activity in mice were studied after 3 weeks of chronic administration of ethanol by liquid diet. When testing was started 24 h after cessation of the ethanol treatment, no differences were seen on the first administration between the effects of the psychostimulants in controls and ethanol-treated animals, but after subsequent daily injections ...
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ژورنال
عنوان ژورنال: Physiology & Behavior
سال: 2012
ISSN: 0031-9384
DOI: 10.1016/j.physbeh.2012.03.014