Excitotoxicity Revisited: Mitochondria on the Verge of a Nervous Breakdown

Excitotoxicity is likely to occur in pathological scenarios which mitochondrial function already compromised, shaping neuronal responses glutamate. In fact, mitochondria sustain cell bioenergetics, tune intracellular Ca2+ dynamics, and regulate glutamate availability by using it as metabolic substrate. Here, we suggest the need explore toxicity context of specific disease models may occur, re-evaluating impact dysfunction on excitotoxicity. Our aim signpost new approaches, perhaps combining pathways rescue function, therapeutic targets neurological disorders.