Excitatory Action of Extracellular ATP on Chick Skeletal Muscle
نویسندگان
چکیده
منابع مشابه
Excitatory action of ATP on embryonic chick muscle.
It has been suggested that ATP might play a role in synaptic transmission at developing vertebrate neuromuscular junctions. To increase our understanding of the events underlying synapse formation, we have used intracellular recording and patch clamp recording to examine the response of chick myoblasts and myotubes to to ATP and other nucleotides, ATP, applied at micromolar concentrations, has ...
متن کاملA receptor that is highly specific for extracellular ATP in developing chick skeletal muscle in vitro.
1. Extracellular adenosine 5'-triphosphate (ATP) activated an early excitatory conductance followed by a late potassium conductance in developing chick skeletal muscle. A series of ATP analogues were tested for their ability to activate these two conductances. All compounds tested were either agonists for both responses or for neither. Furthermore, the potency of agonists was similar for the tw...
متن کاملIrreversible desensitization of ATP responses in developing chick skeletal muscle.
1. In developing chick skeletal muscle, extracellular adenosine 5'-triphosphate (ATP) elicits an early excitatory conductance increase followed by a late potassium conductance increase. Both of these responses desensitize profoundly. Intracellular recordings and whole-cell voltage-clamp recordings were made in order to examine the time course and mechanism of desensitization and the recovery fr...
متن کاملZn2+ potentiates excitatory action of ATP on mammalian neurons.
Despite the increasing recognition that ATP is an important extracellular excitatory mediator in the nervous system, the regulation of ATP receptors is poorly understood. Because the extracellular Zn2+ concentration is regulated in a variety of biological tissues, we studied modulation of the ATP-gated cation channel by Zn2+ in mammalian neurons using the whole-cell patch-clamp technique. In ap...
متن کاملMolecular cloning and characterization of a novel ATP P2X receptor subtype from embryonic chick skeletal muscle.
We have cloned a new P2X ligand-gated ion channel receptor from embryonic chick skeletal muscle, which is tentatively named as chick P2X(8) (cP2X(8)) receptor. The cloned cDNA encodes a protein with 402 amino acids. Electrophysiological study of the recombinant cP2X(8) receptor expressed in Xenopus oocytes showed that 10 microm ATP induced a fast inward current followed by rapid and long lastin...
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ژورنال
عنوان ژورنال: Annals of the New York Academy of Sciences
سال: 1990
ISSN: 0077-8923,1749-6632
DOI: 10.1111/j.1749-6632.1990.tb37713.x