Excitation-contraction coupling in frog ventricle: evidence from voltage clamp studies
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چکیده
منابع مشابه
Depolarization-contraction coupling in short frog muscle fibers. A voltage clamp study
Short muscle fibers (1.5 mm) were dissected from hindlimb muscles of frogs and voltage clamped with two microelectrodes to study phenomena related to depolarization-contraction coupling. Isometric myograms obtained in response to depolarizing pulses of durations between 10 and 500 ms and amplitudes up to 140 mV had the following properties. For suprathreshold pulses of fixed duration (in the ra...
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Relations between the membrane potential and the tension associated with changes in membrane potential were analyzed in barnacle giant muscle fibers by using voltage clamp techniques. With a step change in membrane potential the tension reaches its final level with a time course which is expressed by the difference of two exponential functions. The time constants tau(1) (0.2-0.4 sec at 23 degre...
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In frog fast skeletal muscle, we find a decline of twitch, tetanus, and maximum K and caffeine contracture tensions as tonicity of the bathing solution is increased. The decline of tension independent of the method of producing contraction indicates that the major effect of hypertonicity is directly on contractile tension probably because of the increased internal ionic strength. However, there...
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متن کاملExcitation-Contraction Coupling
Previous studies have demonstrated that the ability of (.adrenergic receptor (.BAR) stimulation to increase cardiac contractility declines with aging. In the present study, the control mechanisms of excitation-contraction (EC) coupling, including calcium current (Ice), cytosolic Ca2" (Ca?') transient and contraction in response to BAR stimulation were investigated in ventricular myocytes isolat...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1971
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1971.sp009656