Excessive Reactive Oxygen Species and Exotic DNA Lesions as an Exploitable Liability

O 22: Reactive Oxygen Species and Epilepsy

Seizure activity has been proposed to result in the generation of reactive oxygen species (ROS), which then contribute to seizure-induced neuronal damage and eventually cell death. Although the mechanisms of seizure-induced ROS generation are unclear, mitochondria and cellular calcium overload have been proposed to have a crucial role. We aim to determine the sources of seizure-induced ROS and ...

Reactive oxygen species and oxidative DNA damage.

Reactive oxygen species (ROS) such as the superoxide anion radical (O2.-) hydrogen peroxide (H2O2) and hydroxyl radical (.OH) have been implicated in the pathophysiology of various states, including ischemia reperfusion injury, haemorrhagic shock, atherosclerosis, heart failure, acute hypertension and cancer. The free radicals, nitric oxide (NO) and O2.- react to form peroxynitrite (ONOO-), a p...

Reactive oxygen species and sperm DNA fragmentation

tau.amegroups.com © Translational Andrology and Urology. All rights reserved. Dr. Dada demonstrated her extensive knowledge about sperm DNA fragmentation (SDF) in her elegantly written commentary with a comprehensive discussion on issues such as genetic health of offspring, value of SDF testing in lifestyle factors, modification of SDF by oocyte, role of sperm preparation, concept of reductive ...

Reactive oxygen species generated by thiopurine/UVA cause irreparable transcription-blocking DNA lesions

Long-term treatment with the anticancer and immunosuppressant thiopurines, azathioprine or 6-mercaptopurine, is associated with acute skin sensitivity to ultraviolet A (UVA) radiation and a high risk of skin cancer. 6-thioguanine (6-TG) that accumulates in the DNA of thiopurine-treated patients interacts with UVA to generate reactive oxygen species. These cause lethal and mutagenic DNA damage. ...

Reactive oxygen species as regulators of oxygen dependent gene expression.