Ex vivo study of use of physiotherapy ultrasound in polymethylmethacrylate beads doped with methylene blue as an antibiotic carrier

Abstract Polymethylmethacrylate bone cement is a standard material used as antibiotic carrier in the orthopedic surgery. The ultrasonic energy method capable of triggering biological effects based on both thermal and non-thermal mechanisms. aim current study to analyze methylene blue dispersion polymethylmethacrylate beads, association with acoustic field generated by ultrasound. Forty-nine specimens were used, each specimen comprised one bead (0.6-mm diameter) doped deposited gelatin sample. Forty test divided into four groups comprising 10 samples, each, different ultrasound intensities (Group 1: 1.0 W/cm2; Group 2: 1.5 W/cm2) depths (A - 2 cm; B 3 cm) control group other nine statistically differed from groups. All irradiated have shown significant differences dispersion, except for Groups 2A 2B. Methylene among was 1A> 1B; 2A> 1A; 2B> 1B. Low-intensity enabled highest when positioned superficial; depth associated high-intensity did not influence dispersion.