Evolving diagnostic criteria for multiple myeloma
نویسندگان
چکیده
منابع مشابه
Evolving diagnostic criteria for multiple myeloma.
Multiple myeloma (MM) is a plasma cell malignancy historically defined by the presence of end-organ damage, specifically, hypercalcemia, renal failure, anemia, and bone lesions (CRAB features) that can be attributed to the neoplastic process. In 2014, the International Myeloma Working Group (IMWG) updated the diagnostic criteria for MM to add specific biomarkers that can be used to make the dia...
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A 60-year-old man presented with an IgG monoclonal paraprotein (50 g/L) and pancytopenia (hemoglobin 77 g/L, white blood count 1.1 109/L, platelets 75 109/L). The bone marrow was hypocellular, lacking in normal hematopoiesis, but contained plasma cells. A diagnosis of multiple myeloma was made and the patient was treated with vincristine, doxorubicin, and dexamethasone, followed by an autologou...
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This literature review presents the most recent developments in the management of multiple myeloma, which is characterized by the presence of abnormal plasma cells (myeloma cells) that accumulate into the bone marrow. Aspects related to pathophysiology, clinical manifestations, laboratory, study and treatment are described. These pieces of information are necessary to accomplish a better ...
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ژورنال
عنوان ژورنال: Hematology
سال: 2015
ISSN: 1520-4391,1520-4383
DOI: 10.1182/asheducation-2015.1.272