Evolutionary Relationship of Protein Sequences of SARS-CoV-2 and Other Viruses through Chaos Game Representation

Comparison between different biological sequences is a key step in bioinformatics when analyzing similarities of and phylogenetic relationships. A method graphically representing known as Chaos Game Representation (CGR) has achieved many applications the studies bioinformatics. The issue application CGR to extract useful features possible from CGR. Initially, was applied DNA sequences, but this paper, CGR-based approach used suitable for comparing protein SARS-CoV-2 other viruses. For aim, several viral 12 groups are considered centroid, amino acid frequency, compounded Shannon entropy, Kullback-Lieber Discrimination Information find inter-relationship among sequences. experimental results demonstrate potential strengths examining evolutionary relationship Our powerful extracting effective therefore important classifying proteins inferring phylogeny