EVOLUTIONARY RELATIONSHIP AND REPURPOSING OF SARS INHIBITORS AGAINST SURFACE GLYCOPROTEIN OF SARS-COV-2

Objective: Coronaviruses are a group of similar viruses which cause fatal infection and responsible for affecting the upper respiratory tract in many organisms. Throughout time these have been found to affect human life by causing major pandemics like SARS, MERS COVID-19 due their high rate mutation zoonotic transmission. Repurposing drug could be solution this challenge, as previously available drugs hold great potential act molecule. Interfering interaction potent mechanism stop viral propagation. Methods: In current study we predicted evolutionary relationship nCoV using three proteins Nucleocapsid phosphoprotein, membrane glycoprotein Envelop protein with accession number YP_009724397, YP_009724393 YP_009724392 respectively. Phylogenetic tree was constructed evaluated bootstrap method. Homology modeling docking studies has done identify binding affinity SARS drugs. Results: shows that phosphoprotein is originated from Hypsugo Bat Coronavirus, Membrane Corona Virus Ferret coronavirus. From result concluded Precose (glide score-8.372) it stable strong Spike glycoprotein. Conclusion: commonly known Acarbose can inhibitor spike This paper described highlighted importance repurposing newly discovered or novel diseases.