Evolutionary dynamics of eukaryotic selenoproteomes: large selenoproteomes may associate with aquatic life and small with terrestrial life
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چکیده
منابع مشابه
Eukaryotic selenoproteins and selenoproteomes.
Selenium is an essential trace element for which both beneficial and toxic effects in human health have been described. It is now clear that the importance of having adequate amounts of this micronutrient in the diet is primarily due to the fact that selenium is required for biosynthesis of selenocysteine, the twenty first naturally occurring amino acid in protein. In this review, we provide an...
متن کاملCharacterization of mammalian selenoproteomes.
In the genetic code, UGA serves as a stop signal and a selenocysteine codon, but no computational methods for identifying its coding function are available. Consequently, most selenoprotein genes are misannotated. We identified selenoprotein genes in sequenced mammalian genomes by methods that rely on identification of selenocysteine insertion RNA structures, the coding potential of UGA codons,...
متن کاملSelenoproteins and selenoproteomes
In the past several years, progress in genome sequencing and development of specialized bioinformatics tools allowed effi cient identifi cation of selenocysteine-containing proteins encoded in completely sequenced genomes. Information is currently available on selenoproteomes from a variety of organisms, including humans, which contain 25 known selenoprotein genes. This review provides basic in...
متن کاملComposition and Evolution of the Vertebrate and Mammalian Selenoproteomes
BACKGROUND Selenium is an essential trace element in mammals due to its presence in proteins in the form of selenocysteine (Sec). Human genome codes for 25 Sec-containing protein genes, and mouse and rat genomes for 24. METHODOLOGY/PRINCIPAL FINDINGS We characterized the selenoproteomes of 44 sequenced vertebrates by applying gene prediction and phylogenetic reconstruction methods, supplement...
متن کاملSensing marine biomolecules: smell, taste, and the evolutionary transition from aquatic to terrestrial life
The usual definition of smell and taste as distance and contact forms of chemoreception, respectively, has resulted in the belief that, during the shift from aquatic to terrestrial life, odorant receptors (ORs) were selected mainly to recognize airborne hydrophobic ligands, instead of the hydrophilic molecules involved in marine remote-sensing. This post-adaptive evolutionary scenario, however,...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2007
ISSN: 1465-6906
DOI: 10.1186/gb-2007-8-9-r198