Evolution of Conus peptide toxins: Analysis of Conus californicus Reeve, 1844
نویسندگان
چکیده
منابع مشابه
A diverse family of novel peptide toxins from an unusual cone snail, Conus californicus.
Diversity among Conus toxins mirrors the high species diversity in the Indo-Pacific region, and evolution of both is thought to stem from feeding-niche specialization derived from intra-generic competition. This study focuses on Conus californicus, a phylogenetic outlier endemic to the temperate northeast Pacific. Essentially free of congeneric competitors, it preys on a wider variety of organi...
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The bioactivities of the venom from Conus lentiginosus were studied from Mumbai coast, are characterized biomedically and pharmaceutically. Partial purification of the crude extract was carried out using DEAE cellulose anion exchange chromatography. The protein content of crude venom was found to be maximum 432.5 ± 1.58 μg/mL and minimum 80.2 ± 1.08 μg/mL. The mice bioassay for lethality was pe...
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Conopeptides are a diverse group of recently evolved venom peptides used for prey capture and/or defense. Each species of cone snails produces in excess of 1000 conopeptides, with those pharmacologically characterized (≈ 0.1%) targeting a diverse range of membrane proteins typically with high potency and specificity. The majority of conopeptides inhibit voltage- or ligand-gated ion channels, pr...
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The pigmentation patterns of shells in the genus Conus can be generated by a neural-network model of the mantle. We fit model parameters to the shell pigmentation patterns of 19 living Conus species for which a well resolved phylogeny is available. We infer the evolutionary history of these parameters and use these results to infer the pigmentation patterns of ancestral species. The methods we ...
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Cone snails, which are predatory marine gastropods, produce a cocktail of venoms used for predation, defense and competition. The major venom component, conotoxin, has received significant attention because it is useful in neuroscience research, drug development and molecular diversity studies. In this study, we report the genomic characterization of nine conotoxin gene superfamilies from 18 Co...
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ژورنال
عنوان ژورنال: Molecular Phylogenetics and Evolution
سال: 2010
ISSN: 1055-7903
DOI: 10.1016/j.ympev.2010.03.029