Evolution of Antigen Variation in the Tick-Borne Pathogen Anaplasma phagocytophilum
نویسندگان
چکیده
منابع مشابه
Evolution of antigen variation in the tick-borne pathogen Anaplasma phagocytophilum.
Anaplasma phagocytophilum is an obligately intracellular tick-transmitted bacterial pathogen of humans and other animals. During the course of infection, A. phagocytophilum utilizes gene conversion to shuffle ∼100 functional pseudogenes into a single expression cassette of the msp2(p44) gene, which codes for the major surface antigen and major surface protein 2 (MSP2). The role and extent of ms...
متن کاملTick-Borne Fever (Anaplasma phagocytophilum Infection) in Sheep – A Review
Ticks may transmit pathogens to ruminants worldwide, creating diseases such as anaplasmosis, babesiosis, ehrlichiosis and theileriosis. In Europe, the most important tick vector is Ixodes ricinus and the most widespread tick-borne infection in animals is Anaplasma phagocytophilum. This infection causes tick-borne fever (TBF) in ruminants, a disease which may not only cause suboptimal growth, bu...
متن کاملPCR for detection of tick-borne Anaplasma phagocytophilum pathogens: a review
Tick-borne infections such as granulocytic anaplasmosis number among emerging infectious diseases. Anaplasma phagocytophilum is an obligate intracellular bacterial parasite infecting the granulocytes of vertebrates. This bacterium is the aetiologic agent of HGA (human granulocytic anaplasmosis). Molecular methods allow quick and accurate detection of pathogens in ticks, humans, or animals. Moni...
متن کاملGlobal Proteomic Analysis of Two Tick-Borne Emerging Zoonotic Agents: Anaplasma Phagocytophilum and Ehrlichia Chaffeensis
Anaplasma phagocytophilum and Ehrlichia chaffeensis are obligatory intracellular α-proteobacteria that infect human leukocytes and cause potentially fatal emerging zoonoses. In the present study, we determined global protein expression profiles of these bacteria cultured in the human promyelocytic leukemia cell line, HL-60. Mass spectrometric (MS) analyses identified a total of 1,212 A. phagocy...
متن کاملPrevalence of human-active and variant 1 strains of the tick-borne pathogen Anaplasma phagocytophilum in hosts and forests of eastern North America.
Anaplasmosis is an emerging infectious disease caused by infection with the bacterium Anaplasma phagocytophilum. In the eastern United States, A. phagocytophilum is transmitted to hosts through the bite of the blacklegged tick, Ixodes scapularis. We determined the realized reservoir competence of 14 species of common vertebrate hosts for ticks by establishing the probability that each species t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2011
ISSN: 0737-4038,1537-1719
DOI: 10.1093/molbev/msr229