Evidence that the E2-isoprostane, 15-E2t-isoprostane (8-iso-prostaglandin E2) is formed in vivo
نویسندگان
چکیده
منابع مشابه
Augmented Vasoconstriction and Thromboxane Formation by 15-F2t-Isoprostane (8-Iso-Prostaglandin F2a) in Immature Pig Periventricular Brain Microvessels
Xin Hou, Fernand Gobeil, Jr, Krishna Peri, Giovanna Speranza, Anne Marilise Marrache, Pierre ) in Immature Pig Periventricular Brain Microvessels α 2 (8-Iso-Prostaglandin F -Isoprostane 2t Augmented Vasoconstriction and Thromboxane Formation by 15-F Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 2000 American Heart Association, Inc. All rights reserved. is published by the American H...
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F2-isoprostanes are isomers of the prostaglandin PGF2alpha. At least one compound of this group, 8-epi-PGF2alpha, exhibits biological activity, and therefore special interest is focused on the mechanism of isoprostane formation: enzyme catalyzed or radical mediated. We analyzed the formation of isoprostanes in vitro and in vivo. In both systems, purified cyclooxygenase isoenzymes and cell model...
متن کاملGeneration of the Isoprostane 8-Epi-prostaglandin F2a In Vitro and In Vivo via the Cyclooxygenases
F2-Isoprostanes are isomers of the prostaglandin PGF2a. At least one compound of this group, 8-epi-PGF2a, exhibits biological activity, and therefore special interest is focused on the mechanism of isoprostane formation: enzyme catalyzed or radical mediated. We analyzed the formation of isoprostanes in vitro and in vivo. In both systems, purified cyclooxygenase isoenzymes and cell models specif...
متن کاملIsoprostane 8-epi-prostaglandin F2 alpha is a potent contractor of human peripheral lymphatics.
Isoprostanes are products of free radical-catalyzed peroxidation and 8-epi-prostaglandin (PG) F2 alpha is the most important vasomodulator of this group of compounds. In human lower leg lymphatics isolated from 5 different patients without a smoking history or hyperlipidemia, 8-epi-PGF2 alpha stimulated in vitro contraction more strongly than the thromboxane receptor agonist U46619. Other isopr...
متن کاملVasodilatory and electrophysiological actions of 8-iso-prostaglandin E2 in porcine coronary artery.
We examined the effects of several E-ring and F-ring isoprostanes on mechanical and electrophysiological activity in porcine coronary artery. Several isoprostanes evoked concentration-dependent contractions, with 8-iso-PGE2 being the most potent (-log EC50 of 6.9 +/- 0.1); this excitatory effect has been described in detail elsewhere and was not examined further here. 8-iso-PGE2 evoked dose-dep...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 1998
ISSN: 0022-2275
DOI: 10.1016/s0022-2275(20)32187-8