Evidence of Linkage with HLA-DR in DRB1*15-Negative Families with Multiple Sclerosis
نویسندگان
چکیده
منابع مشابه
Combination of Myelin Basic Protein Gene Polymorphisms with HLA-DRB1*1501 in Iranian Patients with Multiple Sclerosis
Background: Multiple sclerosis (MS), as a multifactorial autoimmune disease with complex genetic basis, causes demyelination in the central nervous system via cytokine responses to myelin antigens. Myelin basic protein (MBP) is the main protein component of the myelin sheath. HLA-DRB (human leukocyte antigen-DR beta) alleles, particularly HLA-DRB1*1501, may be of significance in the pathogenesi...
متن کاملThree families with amyotrophic lateral sclerosis and frontotemporal dementia with evidence of linkage to chromosome 9p.
BACKGROUND Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative disorders with adult onset that generally progress rapidly after the onset of symptoms. The 2 conditions are independent, but they also overlap in a significant proportion of families, including 2 families in which the disorders are reported to be linked to chromosome 9p. A locus was establish...
متن کاملHLA-DR 15 is associated with female sex and younger age at diagnosis in multiple sclerosis.
BACKGROUND The association between multiple sclerosis and class II alleles of the major histocompatibility complex, in particular the DRB1*1501-DQB1*0602 haplotype, is well established but their role in determining specific features of this clinically heterogeneous disease is unknown as few studies involving large sample sizes have been performed. METHODS 729 patients with multiple sclerosis ...
متن کاملPsychological Changes in Patients With Multiple Sclerosis
Introduction: Multiple Sclerosis (MS) as a stressful event, despite causing negative psychological changes, may lead to positive ones as well. Objective: This study was mainly conducted to examine the implications of posttraumatic growth and demoralization and also to determine the relationship between them in patients with MS. Materials and Methods: This was a cross-sectional study, in which...
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ژورنال
عنوان ژورنال: The American Journal of Human Genetics
سال: 2001
ISSN: 0002-9297
DOI: 10.1086/323480