EVIDENCE INDICATING A CHEMICAL REACTION BETWEEN HYDROXYLAMINE AND RIBOFLAVIN

Evidence indicating a chemical reaction between hydroxylamine and riboflavin.

The observation that hydroxylamine inhibits xanthine oxidase activity through interference with the dehydrogenase portion of the enzyme (1) led us to determine whether hydroxylamine forms a chemical complex with riboflavin or its biological derivatives, riboflavin-5phosphate (FMN) and flavin adenine dinucleotide (FAD). These studies were stimulated by those of Kaplan and his group, who explaine...

Four-Component Reaction between Ethyl Benzoylacetate, Hydroxylamine, Aldehydes and Malononitrile: Synthesis of Isoxazol-5(2H)-Ones

We present herein a new and efficient four-component synthesis of isoxazol-5(2H)-ones involving ring closing/Knoevenagel condensation/Michael addition sequential reactions.

Chemical determination of riboflavin.

Hydroxylamine as an oxygen nucleophile. Direct evidence from its reaction with a phosphate triester

Materials: All solutions were prepared using distilled water. Hydroxylamine (Aldrich, 98%), p-dimethylaminobenzaldehyde (Aldrich, 98%,) fumaric acid (Carlo Erba, 99.5%), succinic acid (Vetec, 99%), tris(hydroxymethyl)aminomethane (TRIS, Aldrich, 99%), N,O-Bis(trimethylsilyl)trifluoroacetamide (Aldrich, >99%) and D2O (Cambridge Isotope Laboratories, 99.9%) were used as supplied. The triester die...

An experimental and theoretical study of reaction mechanisms between nitriles and hydroxylamine.

The industrially relevant reaction between nitriles and hydroxylamine yielding amidoximes was studied in different molecular solvents and in ionic liquids. In industry, this procedure is carried out on the ton scale in alcohol solutions and the above transformation produces a significant amount of unexpected amide by-product, depending on the nature of the nitrile, which can cause further analy...