Evidence for proteolytic activity in liver mitochondria
نویسندگان
چکیده
منابع مشابه
The localization of proteolytic activity in rat liver mitochondria and its relation to mitochondrial swelling and aging.
1. On storage of rat liver mitochondria at 0 degrees , water content, total amino acid content and leakage of protein all rose steadily over a 72hr. period. The initial ratio of intramitochondrial to extramitochondrial amino acid concentration lay between 18 and 24. Initially this rose, but it then fell to 1.9 at the end of storage. The concentration gradient between internal and external amino...
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Both calcium and magnesium ions have been shown to activate the breakdown of ATP’ in whole homogenates of rat liver (2, 3), but purified ATPase from mitochondria was activated only by magnesium (4). Intact mitochondria have yielded divergent results (5, G) with respect to the effect of calcium on their ATPase activity.2 These differences may depend on the state of the mitochondria, as will be s...
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The ATP-Mg/Pi carrier in liver mitochondria is activated by micromolar Ca2+ and mediates net adenine nucleotide transport into and out of the mitochondrial matrix. The purpose of this study was to characterize certain features of ATP-Mg/Pi carrier activity that are essential for understanding how the mitochondrial adenine nucleotide content is regulated. The relative importance of ATP and ADP a...
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In all living tissues, protein constituents are continually being broken down within the body cells and protein decomposition products are excreted. If any or all of the processes of degradation occurring during life are the work of enzymes, we should expect to be able to demonstrate the existence of these enzymes in the tissues after death. The occurrence of such proteolytic enzymes was first ...
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The circulating, endocrine renin-angiotensin system (RAS) is important to circulatory homeostasis, while ubiquitous tissue and cellular RAS play diverse roles, including metabolic regulation. Indeed, inhibition of RAS is associated with improved cellular oxidative capacity. Recently it has been suggested that an intra-mitochondrial RAS directly impacts on metabolism. Here we sought to rigorousl...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1969
ISSN: 0306-3283
DOI: 10.1042/bj1110029pb