Evidence for Placental HPV Infection in Both HIV Positive and Negative Women

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Evidence for Placental HPV Infection in Both HIV Positive and Negative Women

Human papillomaviruses (HPVs) have previously been reported to infect epithelial trophoblast cells of the placenta. To investigate this possibility, 200 placental samples from Zambian women were separated into HIV+ and HIV- groups and tested for HPV by redundant primer PCR, using GP5+/GP6+ and CPI/CPII primer sets. Three HPV genotypes (HPV6, 16 and 90) were detected in placental samples. Wherea...

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Placental HPV Infection in HIV Positive and HIV Negative Zambian Women

Human papillomaviruses (HPVs) have been reported to infect epithelial trophoblastic cells of the placenta, induce cell death and even cause placental malfunction associated with spontaneous preterm delivery. To date, no study has been conducted to determine the role of HIV on HPV genotype distribution and pathogenesis in the placental compartment. This is despite the evidence that the human imm...

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BACKGROUND HPV types vary by country and HIV status. There are no data on the prevalent HPV genotypes from Cameroon. METHODS We conducted a cross-sectional, observational study on 65 Cameroonian women. Samples were sent for HPV genotyping and Thin Prep analyses. RESULTS 41 out of 61 samples tested (67.2%) had HPV subtypes detected. The most common high risk types encountered were: 45 (24.6%...

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ژورنال

عنوان ژورنال: Journal of Cancer Therapy

سال: 2015

ISSN: 2151-1934,2151-1942

DOI: 10.4236/jct.2015.615140