Evidence for diploidy in metacyclic forms of African trypanosomes.
نویسندگان
چکیده
منابع مشابه
Evidence for haploidy in metacyclic forms of Trypanosoma brucei.
The parasitic flagellate Trypanosoma brucei undergoes a series of morphologic and metabolic changes during its passage in the digestive organs of its insect vector, a Glossina or tsetse fly. This morphogenesis ends by the differentiation, in the salivary gland of the fly, of the metacyclic form, which will be transmitted in the bloodstream of the mammalian host. On the basis of DNA microfluorom...
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Successful transmission of the African trypanosome between the mammalian host blood-stream and the tsetse fly vector involves dramatic alterations in the parasite's morphology and biochemistry. This differentiation through to the tsetse midgut procyclic form is accompanied by re-entry into a proliferative cell cycle. Using a synchronous differentiation model and a variety of markers diagnostic ...
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African trypanosomes are devastating human and animal pathogens that cause significant human mortality and limit economic development in sub-Saharan Africa. Studies of trypanosome biology generally consider these protozoan parasites as individual cells in suspension cultures or in animal models of infection. Here we report that the procyclic form of the African trypanosome Trypanosoma brucei en...
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Parasites have developed clt~\'et tricks to evade the deadly immune detense o( d~eu mammalian hosts. Rep.ularly chanting surface coats, that is, anti~enic variation, is one ot the most appealing ~f these trick>. \Vhat ((ruld Be simpler and more effect~\c than t~ fool the immune system ol the host b b regularly changing sudacc al~t igens tllOtt' rapidly thm~ new antibodies can bc made? But m pra...
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Studies on Variant Surface Glycoproteins (VSGs) and antigenic variation in the African trypanosome, Trypanosoma brucei, have yielded a remarkable range of novel and important insights. The features first identified in T. brucei extend from unique to conserved-among-trypanosomatids to conserved-among-eukaryotes. Consequently, much of what we now know about trypanosomatid biology and much of the ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1989
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.86.14.5469