منابع مشابه
Evidence, eminence and extrapolation
A full independent drug development programme to demonstrate efficacy may not be ethical and/or feasible in small populations such as paediatric populations or orphan indications. Different levels of extrapolation from a larger population to smaller target populations are widely used for supporting decisions in this situation. There are guidance documents in drug regulation, where a weakening o...
متن کاملEvidence for risk extrapolation in decision making by tadpoles
Through time, the activity patterns, morphology, and development of both predators and prey change, which in turn alter the relative vulnerability of prey to their coexisting predators. Recognizing these changes can thus allow prey to make optimal decisions by projecting risk trends into the future. We used tadpoles (Lithobates sylvaticus) to test the hypothesis that tadpoles can extrapolate in...
متن کاملTibial eminence fractures.
Tibial eminence fracture, a bony avulsion of the anterior cruciate ligament (ACL) from its insertion on the intercondylar eminence, was first described by Poncet in 1875. Also known as tibial spine fractures, these injuries occur most commonly in skeletally immature patients between the ages of 8 and 14 years. They account for 2% to 5% of knee injuries in the pediatric population and 14% of ACL...
متن کاملSerum urate, menopause, and postmenopausal hormone use: from eminence to evidence-based medicine
The relationship between serum urate, menopause, and aging has not been clearly defined by scientific evidence. In the present issue of Arthritis Research and Therapy, Hak and Choi present a cross-sectional analysis to clarify the effect of menopause and hormone replacement therapy on serum urate in women within the Third National Health and Nutritional Examination Survey. Menopause increased s...
متن کاملMaintaining science eminence.
COVER Partial view of the predictive map of high levels of arsenic in groundwater resources in China (blue, low probability; red, high probability; width, 600 kilometers; resolution, 1 square kilometer). Chronic arsenic poisoning from contaminated groundwater is a major health problem in many parts of China. An estimated 19.6 million people are potentially exposed to elevated arsenic concentrat...
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ژورنال
عنوان ژورنال: Statistics in Medicine
سال: 2016
ISSN: 0277-6715,1097-0258
DOI: 10.1002/sim.6865