EVALUATOIN OF GENOTOXICITY OF RICINUS COMMUNIS (LEAVES AND SEEDS) BY THEIR SILVER NANO-PARTICLES USING COMET ASSAY

Ricinus communis commonly known as castor oil plant is used in Indian indigenous medicinal system of Ayurveda to treat various diseases like sleeping disorders (insomnia), gall bladder pain, headache, backache, expulsion placenta and arthritis. The present study deals with the genotoxic effects silver nanoparticles leaves seeds aqueous extracts human lymphocytes Escherichia coli by comet assay. Using powder communis, nano particles are prepared. results showed increase tail length when E. samples were treated four different concentrations nanoparticles, concentration increases also denoting DNA damage at high concentrations. Mild genotoxicity was observed against nanoparticles. When seed (four concentrations) coli, mild but lymphocytes, higher level genomic (nature increasing concentration).