Evaluation the cardiopulmonary markers in cecal ligation and puncture induced sepsis in Wistar rats
نویسندگان
چکیده
منابع مشابه
Cecal ligation and puncture induced sepsis
Purpose: Multiresistant and vancomycin resistant Enterococcus faecium (VRE) can cause serious infections in hospitalized patients with various co-morbid diseases. We investigated the course of VRE peritonitis after cecal ligation and puncture (CLP)-induced sepsis and compared this to sham operated mice. Methods: Mice were subjected to CLP or sham surgery. Forty-eight hours thereafter four group...
متن کاملA New Approach to Monitoring and Evaluation of Cecal Ligation and Puncture Sepsis Model
Background: Sepsis is a systemic inflammatory disease in response to the pathogens that leads to vital organ failures the failure of vital organs. Appropriate animal models should be developed to measure the effectiveness of therapeutic methods. Cecal Ligation and Puncture (CLP) is the most widely used methods of creating the sepsis model. Some variables interfere in the creation of the CLP mod...
متن کاملProtective effects of curcumin on hepatocytes in cecal ligation and puncture-induced sepsis in rats
We aim to observe the protective effects of curcumin in hepatocytes in septic rat. Sprague-Dawley rats were randomly divided into six groups of 20 rats each: sham group; model group; xuebijing group; low dose group (50 mg/kg), middle dose group (100 mg/kg) and high dose group (150 mg/kg). Another 60 rats were randomly divided into the six above-mentioned experimental groups of 10 rats each to d...
متن کاملRole of hydrogen sulfide in cecal ligation and puncture-induced sepsis in the mouse.
Endogenous hydrogen sulfide (H(2)S) is naturally synthesized in various types of mammalian cells from l-cysteine in a reaction catalyzed by two enzymes, cystathionine-gamma-lyase (CSE) and/or cystathionine-beta-synthase. The latest studies have implied that H(2)S functions as a vasodilator and neurotransmitter. However, so far there is little information about the role played by H(2)S in system...
متن کاملSuppression of PTRF alleviates the polymicrobial sepsis induced by cecal ligation and puncture in mice.
BACKGROUND Sepsis and sepsis-associated organ failure are devastating conditions. Understanding the detailed cellular/molecular mechanisms involved in sepsis should lead to the identification of novel therapeutic targets. METHODS Cecal ligation and puncture (CLP) was used as a polymicrobial sepsis model in vivo to determine mortality and end-organ damage. Macrophages were adopted as the cellu...
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ژورنال
عنوان ژورنال: Journal of Contemporary Medical Sciences
سال: 2020
ISSN: 2413-0516,2415-1629
DOI: 10.22317/jcms.v6i5.864