Evaluation of the hypolipidemic effect of Gangaria de flush herbal mixture in streptozotocin-induced diabetic male rats

Diabetes mellitus is a complex multifarious metabolic disorder characterized by chronic hyperglycemia that requires non-stop treatment with multiple factors will reduce the risk of long-term complications and drug side effects. Streptozotocin well known for its selective pancreatic islet β-cell cytotoxicity used to induce diabetes in animals. It also interferes cellular oxidative mechanisms. Phytomedicine has been existence since primitive age proven be effective treating this condition. This study was aimed at evaluating effect Gangaria de flush (Gdf) herbal mixture on lipid profile streptozotocin (STZ) (60mg/kg) induced diabetic rat. The rats were treated (0.3ml/kg body weight) Glibenclamide (5mg/kg 7days. effects both glibenclamide analyzed. showed reduction significant percentage 45.9% total cholesterol, 65.7% triglyceride, 63.5% low-density lipoprotein, 65.8% very lipoprotein as against negative control 7.6% increase high density lipoprotein. (p<0.05) positive profile. Hence, it can suggested maintaining level.