Evaluation of the HOXA9 and MEIS1 genes as a potential biomarker in adult acute myeloid leukemia

Abstract Background Acute myeloid leukemia (AML) is a heterogeneous disorder encompassing set of hematopoietic tumors that develop when the precursor cells undergo disproportionate clonal proliferation. Homeobox A 9 ( HOXA9 ) pioneer transcription factor in AML pathogenesis along with its cofactor ecotropic integration site 1 MEIS1 ). Our work aimed to evaluate different expression levels and genes their diagnostic prognostic significance adult Egyptian patients de novo AML. The study was carried out on 91 41 healthy individuals. Bone marrow samples were obtained from both controls then tested by reverse transcription-quantitative polymerase chain reaction assess mRNA studied genes. Results gene significantly elevated compared p < 0.001). There statistically significant positive correlation between patients. However, there no association disease-free survival (DFS) overall (OS) = 0.264 0.351, respectively). Conclusion are highly expressed patients, suggesting interesting pathogenic role They could be used as markers for diagnosis AML, but not disease prognosis.