Evaluation of the efficacy and safety of home treatment with the recombinant human C1-inhibitor in hereditary angioedema resulting from C1-inhibitor deficiency
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چکیده
منابع مشابه
Home treatment with conestat alfa in attacks of hereditary angioedema due to C1-inhibitor deficiency
Methods We analyzed 137 edematous episodes requiring acute treatment and occurring in 6 C1-INH-HAE patients. The patients were treated at home with a dose of 2100 U rhC1-INH per occasion. They recorded the time of rhC1INH administration, time until the symptoms stopped worsening, time to the onset of symptom relief and to the complete resolution of symptoms. Any side effects were recorded in ad...
متن کامل84 Immuno-Safety of Recombinant Human C1 Inhibitor in Patients With Hereditary Angioedema: An Integrated Analysis
84 Immuno-Safety of Recombinant Human C1 Inhibitor in Patients With Hereditary Angioedema: An Integrated Analysis Erik Hack, MD, PhD, Anurag Relan, MD, Leonard Kaufman, PhD, and Rienk Pijpstra, MD. Department of Immunology, Dermatology/Allergology & Reumatology, University Medical Center, Utrecht, Utrecht, Netherlands; Pharming Technologies BV, Leiden, Netherlands; Veeda Clinical Research, Brus...
متن کامل85 Clinical Efficacy of Recombinant Human C1 Inhibitor in Patients with Acute Hereditary Angioedema Attacks
84 Immuno-Safety of Recombinant Human C1 Inhibitor in Patients With Hereditary Angioedema: An Integrated Analysis Erik Hack, MD, PhD, Anurag Relan, MD, Leonard Kaufman, PhD, and Rienk Pijpstra, MD. Department of Immunology, Dermatology/Allergology & Reumatology, University Medical Center, Utrecht, Utrecht, Netherlands; Pharming Technologies BV, Leiden, Netherlands; Veeda Clinical Research, Brus...
متن کاملDiagnosis and treatment of hereditary angioedema with normal C1 inhibitor
Until recently it was assumed that hereditary angioedema is a disease that results exclusively from a genetic deficiency of the C1 inhibitor. In 2000, families with hereditary angioedema, normal C1 inhibitor activity and protein in plasma were described. Since then numerous patients and families with that condition have been reported. Most of the patients by far were women. In many of the affec...
متن کاملRecombinant and Plasma-Purified Human C1 Inhibitor for the Treatment of Hereditary Angioedema
BACKGROUND : Agents for prophylaxis of hereditary angioedema (HAE) have been available in the United States for several decades, but their usefulness is limited by side effects and they cannot be used at all in some patients. No agents have been available in the United States to specifically treat acute attacks. HAE types I and II are associated with low functional levels of C1 inhibitor, and e...
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ژورنال
عنوان ژورنال: International Immunopharmacology
سال: 2020
ISSN: 1567-5769
DOI: 10.1016/j.intimp.2020.106216