Evaluation of Serum s EGFR in Ovarian Tumors, its Comparison with Serum CA125, HE4 and Correlation with Histopathological Types

EGFR is deregulated, in several types of cancer, by three mechanisms: (1) activating gene mutations; (2) overexpression the transmembrane form and (3) altered ligand expression. Selective inhibitors have been suggested as first-line therapy lung cancer patients harboring mutations, tumors pancreas certain histotypes ovarian tumors. Carbohydrate antigen 125(CA125) Human Epididymis 4 are being used routinely for detection follow up globally. A comparative observational study, over a 40 samples was carried out using Pre-operative Post-operative Measurement CA125 HE4 chemiluminescence sEGFR ELISA (Bioassay Technology Laboratory, Cat. No.E0313Hu). Results were compared between markers various histological tumor Statistical analysis (SPSS version 21.0). combined panel serum sEGFR, CA125, increases specificity efficiency diagnosis.