Evaluation of seaweed sulfated polysaccharides as natural antagonists targeting Salmonella typhi OmpF: molecular docking and pharmacokinetic profiling

Abstract Background Salmonella belongs to the Enterobacteriaceae family, a gram-negative, non-spore-forming, rod-shaped, motile, and pathogenic bacteria that transmit through unhygienic conditions. It is estimated 21 million new infections arise every year, resulting in approximately 200,000 deaths. more prevalent among children, old aged, immunocompromised individuals. The frequent usage of classical antimicrobials has begun increasing emergence various drug-resistant bacterial strains. Hence, this study was intended evaluate bioactive seaweed sulfated polysaccharides (SSPs) against ompF (outer membrane porin F) protein target typhi . SSP compound with wide range biological activities, such as anti-microbial, anti-allergy, anti-cancer, anti-coagulant, anti-inflammation, anti-oxidant, anti-viral. Results In study, eleven compounds were targeted S. OmpF by molecular docking approach compared two commercially available typhoid medications. showed good binding affinity commercial drugs, particularly carrageenan/MIV-150, carrageenan lambda, fucoidan, 3-phenyllactate, ranked top antagonists Further, pharmacokinetics toxicology (ADMET) studies corroborated possessed drug-likeness highly progressed all parameters. Conclusions AutoDockTools Schrodinger's QikProp module results suggest could be promising drug for extensively (XDR) typhi. To best our knowledge, first report on silico analysis , thus implying capabilities SSPs especially like carrageenans, potential anti-microbial agent infections. Eventually, advanced corroborate next level application crisis XDR microbial diseases. Graphical