Evaluation of polyoxyethylene homopolymers for buccal bioadhesive drug delivery device formulations

A review on bioadhesive buccal drug delivery systems: current status of formulation and evaluation methods

Owing to the ease of the administration, the oral cavity is an attractive site for the delivery of drugs. Through this route it is possible to realize mucosal (local effect) and transmucosal (systemic effect) drug administration. In the first case, the aim is to achieve a site-specific release of the drug on the mucosa, whereas the second case involves drug absorption through the mucosal barrie...

Bioadhesive Drug Delivery Systems

Bioadhesive Microspheres for Tuberculosis Drug Delivery

Tuberculosis (TB) is an infectious disease that mainly affects the lungs. For the treatment of tuberculosis, conventional drug delivery system fails to achieve efficient drug delivery system fails to achieve efficient drug delivery at the target site. Today, bioadhesive microspheres became a topic of great interest as a novel carrier for drug delivery. Bioadhesive microspheres offers longer ret...

Bioadhesive Mini-Tablets for Vaginal Drug Delivery

Different non-ionic cellulose ethers (methyl cellulose, MC; hydroxyethyl cellulose, HEC; hydroxypropyl cellulose, HPC; hydroxypropylmethyl cellulose, HPMC) and microcrystalline cellulose (MCC) were investigated as matrix formers for preparation of mini-tablets targeting vaginal drug delivery. Hexyl aminolevulinat hydrochloridum (HAL) was used as a model drug. The mini-tablets were characterized...

Drug Delivery: Plant Lectins as Bioadhesive Drug Delivery Systems

Selective targeting of drugs to the proposed site of action provides therapeutic advantages such as reduced toxicity and smaller dose levels. Despite a huge progress made in drug design and delivery systems, many challenges still have to be solved. Small therapeutic drugs always have the potential to pass into the kidneys and be excreted from the body. The use of macromolecular constructs (carr...