Evaluation of optical coherence tomography angiography parameters in patients treated with Hydroxychloroquine

Abstract Background One of the major side effects Hydroxychloroquine (HCQ) is retinopathy. The aim this study was to evaluate Optical coherence tomography angiography (OCTA) parameters in a group patients who have Hydroxychloroquine-induced retinopathy based on Multifocal electroretinography (mfERG) with do not Method This Cross-Sectional Study. In study, Rheumatoid arthritis (RA) or Systemic lupus erythematosus (SLE) had been taking for at least 7 years were included. MfERG and OCTA imaging performed all patients. Patients divided into Normal mfERG Abnormal groups results. studied these two groups. Result Sixty-one (61 eyes) Forty-one SLE 20 RA. Forty (66.7%) mfERG. mean vascular density (VD) Superficial capillary plexus (SCP) layer significantly different between ( P -Value> 0.05). Mean VD SCP RA subgroup, PeriFovea region lower than normal -Value < deep (DCP) Whole Image, Superior Hemi, Inferior area discrepancy also observed subgroup but subgroup. none foveal avascular zone (FAZ) (mm2), Flow Area Outer Retina (mm2) Choriocapillaris statistically significant p -value> Conclusion DCP decreased abnormal compared But it seems that layer, FAZ are similar both may be used as non-invasive tool diagnosis early stages HCQ-induced retinopathy, especially patients, further studies needed.