Evaluation of miRNA-21 and CA-125 as a promising diagnostic biomarker in patients with ovarian cancer

Abstract Introduction/objective Ovarian cancer is the 6th leading cause of mortality in women, killing more women than any other reproductive system cancer. We studied expression serum micro-ribonucleic acid-21 ( miRNA-21 ) ovarian patients and explored associations with diagnosis, clinicopathological parameters, prognosis. Methods Real-time fluorescence-quantitative polymerase chain reaction was used to examine relative serum. Cancer antigen 125 (CA-125) levels were measured using an enzyme immunoassay test kit (ELISA). Results Serum miR-21 significantly elevated compared controls p < 0.001). The same true for CA-125 levels, which also sensitivity specificity detection diagnosis 96%, 88% versus 74%, 80% CA-125. Conclusions highly expressed may be important development progression cancer, Our results suggest that circulating a promising tumor marker use prognosis