Evaluation of immature granulocyte parameters in myeloid neoplasms assayed by Sysmex XN hematology analyzer

Abstract Immature granulocytes (IGs) have significance for the diagnosis of myeloid neoplasms (MNs). The current study aims to use a hematology analyzer evaluate accuracy IG parameters in MNs. Blood specimens from 388 patients with MN, 524 non-hematological (non-HNs), including 109 inflammation and 68 undergoing G-CSF administration, 500 healthy control subjects were analyzed. was assayed by Sysmex XN-9000 (XN) compared manual assessments. A high level agreement between IG% derived XN measurements MN ( r = 0.828, p < 0.0001) revealed but only moderate correlation acute leukemia (AML; 0.597; 0.0001). Bland–Altman bias analysis conducted, results showed that differences considered clinically insignificant. ROC demonstrated good performance IG# (AUC 0.842) 0.885) assessed cut-off values 0.200 × 10 9 /L 1.95%, respectively. are helpful screening MNs even though granulocyte morphological abnormalities may interfere parameter accuracy.