Evaluation of drug-drug interactions in critically ill pediatric patients

Purpose: The aim of this study was to determine the drug-drug interactions that are frequently encountered in critically ill patients and factors predict these interactions. 
 Materials Methods: All who were admitted pediatric intensive care unit (13 bed) a university hospital used more than one drug their treatment included prospective cross-sectional study. Patients' demographics, laboratory findings, medications evaluated daily by clinical pharmacist. UpToDate® database detect potential Results: During study, 797 detected 55 (83.33%) 66 followed. pharmacist 114 recommendations made physicians following regarding Eighty-five (74.56%) accepted physicians. Within scope each patient followed up for median 9 (2-63) days, value during period calculated as 7 (1-89). Conclusion: existence pDDIs significantly associated with number prescribed medications. Exposure is frequent related Daily close cooperation between clinicians pharmacists recommended prevent harmful outcomes DDIs. In order minimize risk, it avoid polypharmacy much possible offer alternatives inducer inhibitor drugs treatment.