Evaluation of Changes in the Ganglionic Cell inner Plexiform Layer and Macular Retinal Nerve Fiber Layer in Patients Receiving Hydroxychloroquine

Backgrounds: To evaluate changes in the thickness of ganglion cell-inner plexiform layer and macular retinal nerve fiber using ocular coherence tomography patients exposed to hydroxychloroquine .
 Methods: This was a retrospective, cross-sectional study on therapy. Ocular images showing cell were obtained compared controls. The relationship between layer, duration cumulative dose evaluated.
 Results: In all, 219 subjects included. Thickness significantly less than controls (p = 0.006). average RNFL control groups, but not statistically significant 0.389). There no correlation ganglionic with duration, daily dose, or hydroxychloroquine.
 Conclusion: Thinning cell- inner could be an early indicator toxicity before appearance clinical retinopathy.