Evaluation of antidiabetic effect of nanoselenium in STZ induced diabetes in rats

This study was designed to investigate the anti-diabetic effects of selenium nanoparticles (SeNPs) at dose 2 mg/kg body weight in streptozotocin (STZ) induced diabetes rats 50 weight. Were administered orally normal and experimentally diabetic for 35 days glibenclamide (Glib) rate 20 used as a reference drug. 48 waster male divided into 6 equal groups each 8 rats. Blood samples pancreatic tissue were collected end experimental. Animals either treated with SeNPs its results demonstrated that could significantly decreased blood glucose levels, enhanced serum insulin concentration, Result showed decrease liver function alanine aminotransferase (ALT) aspartate (AST), cardiac creatine kinase-MB (CK-MB). total cholesterol, triglyceride low density lipoprotein (LDL) levels high (HDL) increased. Histological finds able prevent atrophy island Langerhans cells compared uncontrolled group