Evaluation of Antiaging Effect of Sheep Placenta Extract Using SAMP8 Mice

Widely used in traditional medicine, sheep placenta extract (SPE) is known for its physiological effects such as wound healing, antioxidant, and anti-inflammatory properties. However, the effect of SPE on antiaging still unclear. In this study, we investigated aging through senescence-accelerated mouse prone 8 (SAMP8) strain. We designed an experiment using both male female mice randomly divided into 4 groups (n = 10) follows: Group A—control group; B—low-dose (61.5 mg/kg BW/day); C—medium-dose (123 D—high-dose (184.5 BW/day). As a result measuring index parameters skin glossiness, spine lordosis, kyphosis, it was found that treatment lowered index. addition, biochemical lactic acid, glucose, ketone bodies, free fatty acids, tumor necrosis factor-alpha (TNF-?), interleukin 6 (IL-6) were not changed experimental group treated with 13 weeks. Finally, lipid peroxidation (LPO) decreased, while activities catalase superoxide dismutase (SOD) significantly increased brain tissues SPE-treated mice. Supplementation oxidative stress caused by process without toxicity decreased index, suggesting value effective treatment.