Evaluation of a melanocortin-4 receptor (MC4R) agonist (setmelanotide) in MC4R deficiency
نویسندگان
چکیده
منابع مشابه
Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency
OBJECTIVE Pro-opiomelanocortin (POMC)-derived peptides act on neurons expressing the Melanocortin 4 receptor (MC4R) to reduce body weight. Setmelanotide is a highly potent MC4R agonist that leads to weight loss in diet-induced obese animals and in obese individuals with complete POMC deficiency. While POMC deficiency is very rare, 1-5% of severely obese individuals harbor heterozygous mutations...
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............................................................................................................................. ii Acknowledgements ............................................................................................................ iv List of Tables ................................................................................................................... vii List...
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ژورنال
عنوان ژورنال: Yearbook of Paediatric Endocrinology
سال: 2018
ISSN: 1662-4009
DOI: 10.1530/ey.15.11.6