Evaluating epistatic interaction signals in complex traits using quantitative traits
نویسندگان
چکیده
منابع مشابه
Evaluating epistatic interaction signals in complex traits using quantitative traits
Rheumatoid arthritis (RA) is a complex, chronic inflammatory disease implicated to have several plausible candidate loci; however, these may not account for all the genetic variations underlying RA. Common disorders are hypothesized to be highly complex with interaction among genes and other risk factors playing a major role in the disease process. This complexity is further magnified because s...
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The interaction between segregation distortion loci (SDL) has been often observed in all kinds of mapping populations. However, little has been known about the effect of epistatic SDL on quantitative trait locus (QTL) mapping. Here we proposed a multi-QTL mapping approach using epistatic distorted markers. Using the corrected linkage groups, epistatic SDL was identified. Then, these SDL paramet...
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The doubled-haploid (DH) barley population (Harrington x TR306) developed by the North American Barley Genome Mapping Project (NABGMP) for QTL mapping consisted of 145 lines and 127 markers covering a total genome length of 1270 cM. These DH lines were evaluated in approximately 25 environments for seven quantitative traits: heading, height, kernel weight, lodging, maturity, test weight, and yi...
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With a large number of quantitative trait loci being identified in genome-wide association studies, researchers have become more interested in detecting interactions among genes or single nucleotide polymorphisms (SNPs). In this research, we carried out a two-stage model selection procedure to detect interacting gene pairs or SNP pairs associated with four important traits of outbred mice, incl...
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Introduction In the chapter on Mendel and Morgan, we saw how the transmission of genes from one generation to another follows precise mathematical formula. The traits discussed in that chapter, however, were discrete traits—peas are either yellow or green, someone either has a disorder or does not have the disorder. But many behavioral traits are not like these clear-cut, have-it-or-don’t-have-...
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ژورنال
عنوان ژورنال: BMC Proceedings
سال: 2009
ISSN: 1753-6561
DOI: 10.1186/1753-6561-3-s7-s82